These mutations all result in the same scientific phenotype, because while different mutations impair signaling at different stages presumably, each of them impair the power of STAT3 to bind to DNA and induce gene transcription (11). were identified also, this time around in sufferers who offered early starting point autoimmunity … Continue reading These mutations all result in the same scientific phenotype, because while different mutations impair signaling at different stages presumably, each of them impair the power of STAT3 to bind to DNA and induce gene transcription (11)